림프계 손상에 따른 조직과 미세환경의 변화

서미리¹^,^*

Change of Tissue and Microenvironment Following Lymphatic Injury

Mi Ri Suh¹^,^*

¹차의과학대학교 분당차병원 재활의학교실

¹Department of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, Republic of Korea

^*Address for correspondence: Mi Ri Suh, MD, Department of Rehabilitation Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Yatapro 59, Bundang-gu, Seongnam-si, Gyeonggido 13496, Republic of Korea, Tel: +82-31-780-2942, Fax: +82-31-780-3449, E-mail: suhmiri@gmail.com

ⓒ Copyright 2026 Korean Society of Lymphology and Lymphedema. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: May 17, 2023; Accepted: May 19, 2023

Published Online: May 31, 2023

Abatract

Injured lymphatic system during cancer treatment undergoes chronic inflammation via T cell mediated immune response, leading to increased lymphatic leakiness, decreased lymphatic pumping, and increased tissue fibrosis. New lymphatic vessels are regenerated by lymphangiogenesis in effort to restore the injured lymphatic pathways. Detour pathways and dermal backflows are other anatomical responses to develop new lymphatic drainage pathway following the injury.

Keywords: Lymphedema; Microenvironment; Tissue; Inflammation