림프부종과 섬유화

박종범¹^,^*

Fibrosis, Tissue Change and Lymphedema

Jong Bum Park¹^,^*

¹건양대학교 의과대학 건양대학교병원 재활의학과

¹Department of Rehabilitation Medicine, Konyang University College of Medicine, Daejeon, Republic of Korea

^*Address for correspondence: Jong Bum Park, MD, Department of Rehabilitation Medicine, Konyang University College of Medicine, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Republic of Korea, Tel: +82-42-612-2180, Fax: +82-42-612-2092, E-mail: jbocean@kyuh.ac.kr

ⓒ Copyright 2026 Korean Society of Lymphology and Lymphedema. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Oct 17, 2022; Accepted: Oct 27, 2022

Published Online: Nov 11, 2022

Abatract

Lymphedema has traditionally been regarded as a chronic, progressive disease resulting from damage to the lymphatic drainage system, resulting in the accumulation of interstitial fluid and thus tissue edema. It has been found that it is not simply due to the accumulation of lymph and body fluid in the interstitial tissue, and suggested that a complex series of processes affecting various tissue compartments are involved in the pathophysiology. Fibrosis is an excessive deposition of extracellular matrix in various organs, which may cause abnormalities in the function of the corresponding organ, and fibrosis is an important pathophysiological change in lymphedema. In this review, macroscopic, histopathological, and molecular changes in lymphedema are described.

Keywords: Lymphedema; Fibrosis; Tissues; Inflammation